Veratrylamine → HCID 178490831, compound

HRID 710500Notes

Reaction equation

HRID 710500 reaction equation
O1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]2[N:10]=[CH:11][NH:12][C:8]=2[CH:7]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[CH2:20][NH2:21]>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[CH2:20][N:21]1[CH:5]=[N:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][C:9]2[NH:10][CH:11]=[N:12][C:8]=2[CH:7]=1

Participants

3

Reactant 2

HCID 79832VeratrylamineHCID 58433284HCID 58433284, compound

Product 1

HCID 178490831HCID 178490831, compound

Procedure

The compound was synthesized starting from 5-(1,3,4-oxadiazol-2-yl)benzimidazole (186 mg, 1 mmol) and 3,4-Dimethoxybenzylamine (0.5 ml) as described above; yield: 0.087 g (25.9%); MS m/z: 336.3 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.55 (s, 3H); 3.65 (s, 3H); 5.27 (s, 2H); 6.50 (dd, 1H, 4J=2.1 Hz, 3J=8.3 Hz); 6.64 (d, 1H, 4J=2.1 Hz); 6.81 (d, 1H, 3J=8.3 Hz), 7.62 (dd, 1H, 4J=1.2 Hz, 3J=8.7 Hz); 7.83 (d, 1H, 3J=8.7 Hz); 7.92 (br s, 1H); 8.76 (s, 1H); 8.98 (s, 1H); HPLC (METHOD [A]): rt 7.36 min (100%)

Workup

  1. customThe compound was synthesized
  2. customrt 7.36 min (100%)

Sources & evidence

ORD record
ord-baa57b995b4a4c87ad2359cd8addae90
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

Loading…