Benzenepropanoyl chloride → HCID 178420224, compound

HRID 710522Notes

Reaction equation

HRID 710522 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=O)=[CH:9][C:4]=2[NH:3][CH:2]=1.[C:14]1([CH2:20][CH2:21][C:22](Cl)=O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[CH2:21]([C:22]1[S:34][C:10]([C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[N:12][N:13]=1)[CH2:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 64801Benzenepropanoyl chlorideHCID 87949Lawesson's reagentHCID 166371191H-benzimidazole-5-carbohydrazide

Product 1

HCID 178420224HCID 178420224, compound

Procedure

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg; 1 mmol), TEA (0.153 ml; 1.1 mmol), phenylpropionylchloride (0.163 ml; 1.1 mmol) and Lawesson's reagent (606 mg; 1.5 mmol) as described in method 1; yield: 0.067 g (21.9%);

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-76963735055f4f58b8e2d866a410974c
Source dataset
uspto-grants-2015_11
Patent number
US09181233B2

Reaction notes

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