2-Aminothiazole → HCID 86688551, compound

HRID 710554Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[C:8]1[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]3[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=3)=[N:21][CH:22]=2)=[O:15])[CH2:10][CH2:9]1.[NH2:32][C:33]1[S:34][CH:35]=[CH:36][N:37]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[C:8]1[CH2:9][CH2:10][N:11]([C:14]([NH:16][C:17]2[CH:22]=[N:21][C:20]([C:23]3[CH:24]=[CH:25][C:26]([C:27](=[O:28])[NH:32][C:33]4[S:34][CH:35]=[CH:36][N:37]=4)=[CH:30][CH:31]=3)=[CH:19][CH:18]=2)=[O:15])[CH2:12][CH2:13]1

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 66691817HCID 66691817, compound

Product 1

HCID 86688551HCID 86688551, compoundYield 47%

Procedure

Following the procedure of Example 13, using the compound obtained in Example 28 in place of 2-(4-(pyridin-2-ylmethylene)piperidine-1-carboxamido)thiazole-5-carboxylic acid and using 2-aminothiazole (30 mg, 290 μmol) in place of morpholine, the title compound (45 mg, 47%) was obtained as a white solid.

Sources & evidence

ORD record: ord-47512f488e744481bc72ecd928172a44
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181183B2

Reaction notes

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