反应详情

Crude N-(3,5-Difluoro-4-iodopyridin-2-yl)-N-(propylsulfonyl)propane-1-sulfonamide (obtained in Step 1) was stirred with 5% aqueous sodium hydroxide solution (20 ml) at 60° C. for 1 h. The cooled reaction mixture was then acidified with 10% hydrochloric acid to pH<2 and extracted with DCM. The combined extracts were dried over sodium sulfate, filtered, and concentrated. The residue was chromatographed on silica gel (20-30% ethyl acetate in hexanes eluant) to provide the title compound. MS m/z 363.1 (M+1).

1. customThe cooled reaction mixture
2. extractionextracted with DCM
3. dry with materialThe combined extracts were dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel (20-30% ethyl acetate in hexanes eluant)