Hydrochloric Acid → HCID 118492327, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(3-Bromophenyl)-4-oxo-1,4-dihydropyridino[2,3-c]pyridazine-3-carboxylic acid ethyl ester (3.6 g, 9.6 mmol) in methanol(50 mL) was added potassium hydroxide (5.3 g, 94.6 mmol), heated to 65° C. and reacted for 3 h. Dilute hydrochloric acid was added to regulate pH to 5-6, solvent was removed by distillation, 50 mL water was added, filtrated to obtain product 3.25 g.

Provenance & Evidence