Hydrochloric Acid → HCID 118492327, compound

HRID 710603Notes

Reaction equation

HRID 710603 reaction equation
C([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:22]=[CH:21][CH:20]=[N:19][C:9]=2[N:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Br:18])[CH:13]=2)[N:11]=1)=[O:5])C.[OH-].[K+].Cl>CO>[Br:18][C:14]1[CH:13]=[C:12]([N:10]2[C:9]3[N:19]=[CH:20][CH:21]=[CH:22][C:8]=3[C:7](=[O:23])[C:6]([C:4]([OH:5])=[O:3])=[N:11]2)[CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 118492331HCID 118492331, compound

Product 1

HCID 118492327HCID 118492327, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
65 °C

Procedure

To 1-(3-Bromophenyl)-4-oxo-1,4-dihydropyridino[2,3-c]pyridazine-3-carboxylic acid ethyl ester (3.6 g, 9.6 mmol) in methanol(50 mL) was added potassium hydroxide (5.3 g, 94.6 mmol), heated to 65° C. and reacted for 3 h. Dilute hydrochloric acid was added to regulate pH to 5-6, solvent was removed by distillation, 50 mL water was added, filtrated to obtain product 3.25 g.

Workup

  1. customreacted for 3 h
  2. customwas removed by distillation, 50 mL water
  3. additionwas added
  4. filtrationfiltrated

Sources & evidence

ORD record
ord-f10b5c3ccfa840d9866268f4658bee11
Source dataset
uspto-grants-2015_11
Patent number
US09181244B1

Reaction notes

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