Potassium Hydroxide → HCID 57876393, compound

HRID 710834Notes

Reaction equation

HRID 710834 reaction equation
[CH3:1][C:2]1([CH3:17])[C:14]2[C:13]3[CH:12]=[C:11]([CH3:15])[CH:10]=[CH:9][C:8]=3[NH:7][C:6]=2[CH2:5][CH2:4][N:3]1[CH3:16].[F:18][C:19]([F:29])([F:28])[C:20]1[CH:25]=[CH:24][C:23]([CH:26]=[CH2:27])=[CH:22][N:21]=1.[OH-].[K+]>CN1C(=O)CCC1>[F:29][C:19]([F:18])([F:28])[C:20]1[N:21]=[CH:22][C:23]([CH2:26][CH2:27][N:7]2[C:8]3[CH:9]=[CH:10][C:11]([CH3:15])=[CH:12][C:13]=3[C:14]3[C:2]([CH3:17])([CH3:1])[N:3]([CH3:16])[CH2:4][CH2:5][C:6]2=3)=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 574168485-Ethenyl-2-(trifluoromethyl)pyridineHCID 68925523HCID 68925523, compound

Product 1

HCID 57876393HCID 57876393, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-1,1,2,8-tetramethyl-1H-pyrido[4,3-b]indole, 2-(trifluoromethyl)-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Workup

  1. customranging between 25 deg C
  2. customto 100 deg C
  3. customThe product obtained
  4. customis isolated by preparative HPLC

Sources & evidence

ORD record
ord-c151df6a854e49f1b52d9202f338ee12
Source dataset
uspto-grants-2015_11
Patent number
US09181240B2

Reaction notes

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