Potassium Hydroxide → HCID 57876212, compound

HRID 710840Notes

Reaction equation

HRID 710840 reaction equation
[CH3:1][N:2]1[CH2:15][CH2:14][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][C:12]=3[C:4]=2[CH2:3]1.[F:16][C:17]([F:31])([F:30])[C:18]1[N:23]=[CH:22][C:21]([C:24](=[CH2:29])[C:25]([O:27][CH3:28])=[O:26])=[CH:20][CH:19]=1.[OH-].[K+]>CN1C(=O)CCC1>[F:30][C:17]([F:16])([F:31])[C:18]1[N:23]=[CH:22][C:21]([CH:24]([CH2:29][N:6]2[C:7]3[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][C:12]=3[C:4]3[CH2:3][N:2]([CH3:1])[CH2:15][CH2:14][C:5]2=3)[C:25]([O:27][CH3:28])=[O:26])=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 2092911H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2,8-dimethyl-HCID 68735010HCID 68735010, compound

Product 1

HCID 57876212HCID 57876212, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, methyl 2-(6-(trifluoromethyl)pyridin-3-yl)acrylate and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Workup

  1. customranging between 25 deg C
  2. customto 100 deg C
  3. customThe product obtained
  4. customis isolated by preparative HPLC

Sources & evidence

ORD record
ord-7e1b2383fb7847a2b18d1a0350c9a18b
Source dataset
uspto-grants-2015_11
Patent number
US09181240B2

Reaction notes

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