Trifluoroacetic acid → HCID 117988641, compound

HRID 710972Notes

Reaction equation

C([N:5]([CH2:9][CH2:10][C:11]([NH:13][NH:14][C:15]([C@@H:17]1[CH2:23][CH2:22][C@@H:21]2[CH2:24][N:18]1[C:19](=[O:30])[N:20]2[O:25][S:26]([OH:29])(=[O:28])=[O:27])=[O:16])=[O:12])C(=O)[O-])(C)(C)C.[NH+]1C=CC=CC=1.FC(F)(F)C(O)=O>>[NH2:5][CH2:9][CH2:10][C:11]([NH:13][NH:14][C:15]([C@@H:17]1[CH2:23][CH2:22][C@@H:21]2[CH2:24][N:18]1[C:19](=[O:30])[N:20]2[O:25][S:26]([OH:29])(=[O:27])=[O:28])=[O:16])=[O:12]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 118074098HCID 118074098, compound

Product 1

HCID 117988641HCID 117988641, compoundYield 72.3%

Procedure

All the amount of the above pyridine salt was deprotected with trifluoroacetic acid, and purified by octadecyl silica gel column chromatography to afford 191 mg of the title compound (yield 72.3%).

Workup

custompurified by octadecyl silica gel column chromatography

Sources & evidence

ORD record: ord-cbc4b125cbea4acc88acc870b6da0075
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181250B2

Reaction notes

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