Trifluoroacetic acid → HCID 117988114, compound

HRID 710975Notes

Reaction equation

HRID 710975 reaction equation
C([N:5]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([NH:18][NH:19][C:20]([CH:22]2[CH2:28][CH2:27][CH:26]3[CH2:29][N:23]2[C:24](=[O:35])[N:25]3[O:30][S:31]([OH:34])(=[O:33])=[O:32])=[O:21])=[O:17])=[CH:12][CH:11]=1)C(=O)[O-])(C)(C)C.[NH+]1C=CC=CC=1.FC(F)(F)C(O)=O>>[NH2:5][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]([NH:18][NH:19][C:20]([CH:22]2[CH2:28][CH2:27][CH:26]3[CH2:29][N:23]2[C:24](=[O:35])[N:25]3[O:30][S:31]([OH:34])(=[O:33])=[O:32])=[O:21])=[O:17])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118073950HCID 118073950, compound

Product 1

HCID 117988114HCID 117988114, compoundYield 48.7%

Procedure

All the amount of the pyridine salt was deprotected with trifluoroacetic acid, and purified by DIAION HP21 (MITSUBISHI CHEMICAL) to afford 100.3 mg of the title compound (yield 48.7%).

Workup

  1. custompurified by DIAION HP21 (MITSUBISHI CHEMICAL)

Sources & evidence

ORD record
ord-13acad5e97534522b9ab8b9701e4f919
Source dataset
uspto-grants-2015_11
Patent number
US09181250B2

Reaction notes

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