反应详情

To a mixture of 8-(3-chloro-4-fluorophenyl)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-methyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (80.0 mg) in methanol (1.8 mL) was added palladium hydroxide (8.0 mg), and the mixture was stirred for 5 days under a hydrogen stream. The catalyst was removed, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (26.0 mg).

1. customThe catalyst was removed
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (methanol/ethyl acetate)