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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 711274Generated: November 1, 2026

Trifluoroacetic acid → (2',5-Dimethyl-3,4'-bipyridin-6-yl)methanamine

https://huagongshe.com/reaction/711274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantN-(2,4-dimethoxybenzyl)-1-(2',5-dimethyl-3,4'-bipyridin-6-yl)methanamineHCID 67208701—
Product(2',5-Dimethyl-3,4'-bipyridin-6-yl)methanamineHCID 67208705—

Reaction Steps

To the reaction vessel containing N-(2,4-dimethoxybenzyl)-1-(2′,5-dimethyl-3,4′-bipyridin-6-yl)methanamine 81-4 (0.54 g, 1.5 mmol) was added trifluoroacetic acid (2 mL). The reaction was stirred at room temperature for 2 hours. TFA was removed by rotary evaporation to give crude (2′,5-dimethyl-3,4′-bipyridin-6-yl)methanamine 81-5. MS m/z 214.2 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181235B2
Source datasetuspto-grants-2015_11
ORD IDord-fca9816e122f4deeb6e8ba457a926f37
Source noteuspto-grants-2015_11