Acetic Acid → 8-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 711384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 711384
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:12][NH2:13])=[N:9]2)=[CH:4][CH:3]=1.[C:14](O)(=O)[CH3:15]>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]3[N:9]2[C:14]([CH3:15])=[N:13][N:12]=3)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 176Acetic AcidHCID 52002657-Bromo-2-hydrazinylquinoxaline

Produkt 1

HCID 668035548-Bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalineAusbeute 90 %

Versuchsvorschrift

A mixture of 7-bromo-2-hydrazinylquinoxaline (1 g, 4.18 mmol) in acetic acid (10 mL) was refluxed for 18 h. Half of the acetic acid was removed under vacuum and the residue was poured into ice-water. The precipitate was collected on a filter, washed with water, and dried under vacuo to afford crude 8-bromo-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline as a dark red solid (1 g, yield 90%) which was used in the next step without further purification. MS (m/z): 263 (M+H)+.

Aufarbeitung

  1. temperaturewas refluxed for 18 h
  2. customHalf of the acetic acid was removed under vacuum
  3. additionthe residue was poured into ice-water
  4. customThe precipitate was collected on a filter
  5. washwashed with water
  6. customdried under vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5d14d82332fb4e68aafe04a1a681c519
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181264B2

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