Acetyl chloride → HCID 67398744, compound

HRID 711856Notes

Reaction equation

HRID 711856 reaction equation
[OH:1][CH2:2][C:3]([CH3:18])([CH3:17])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:7]=1[C:8]#[N:9].[C:19](Cl)(=[O:21])[CH3:20]>>[C:19]([O:1][CH2:2][C:3]([CH3:18])([CH3:17])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:7]=1[C:8]#[N:9])(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 67401355HCID 67401355, compound

Product 1

HCID 67398744HCID 67398744, compoundYield 66%

Procedure

Prepared as in Example 231c from 2-(3-hydroxy-2,2-dimethylpropoxy)-6-nitrobenzonitrile (Example 233d) and acetyl chloride in 66% yield. 1H NMR (400 MHz, DMSO-d6) δ 1.04 (s, 6H), 2.00 (s, 3H), 3.95 (s, 2H), 4.02 (s, 2H), 7.70-7.72 (m, 1H), 7.85-7.92 (m, 2H).

Sources & evidence

ORD record
ord-a31a330b3097473198ca4933ce0ad410
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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