m-Chloroperbenzoic acid → HCID 66747198, compound

HRID 711879Notes

Reaction equation

HRID 711879 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[C:17]2[C:16]([NH2:18])=[N:15][S:14](=[O:20])(=[O:19])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.C1C=C(Cl)C=C(C(OO)=[O:29])C=1>C(Cl)Cl.CC(O)=O>[CH3:1][S:2]([CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[C:17]2[C:16]([NH2:18])=[N:15][S:14](=[O:19])(=[O:20])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:29]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 66746702HCID 66746702, compound

Product 1

HCID 66747198HCID 66747198, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 21922555Acetic acid methylene chlorideSolvent

Procedure

To a solution of 5-(4-(methylthio)butoxy)-1H-benzo[c][1,2,6]thiadiazin-4-amine-2,2-dioxide (Example 244) (79 mg, 0.25 mmol) in DCM/CH3CO2H (20:1, 20 mL) was added MCPBA (1.0 equiv.) at room temperature. The reaction mixture was then stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and the residue was purified by chromatography on silica gel eluting with 15% MeOH in dichloromethane to give the title compound (74 mg, 90%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 1.74-1.77 (m, 2H), 1.88-1.95 (m, 2H), 2.50 (s, 3H), 2.68-2.73 (m, 1H), 2.77-2.83 (m, 1H), 4.19 (t, 2H), 6.58-6.60 (d, J=8.4 Hz, 1H), 6.73-6.75 (d, J=8.0 Hz, 1H), 7.44 (t, J=8.0 Hz, 1H), 7.79 (s, 1H), 8.33 (s, 1H), 10.92 (s, 1H). MS 332 (MH+).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by chromatography on silica gel eluting with 15% MeOH in dichloromethane

Sources & evidence

ORD record
ord-ce9314503a8b43599b3711ef9577ed58
Source dataset
uspto-grants-2015_11
Patent number
US09181276B2

Reaction notes

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