反应详情

温度

90 °C

A mixture of {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}methyl methanesulfonate (0.20 g, 0.52 mmol) and sodium cyanide (0.057 g, 1.2 mmol) in dimethyl sulfoxide (2 mL) was stirred at 90° C. for 4 h. After diluting with EtOAc, the resulting mixture was washed with sat. NaHCO3 solution, water and brine, then concentrated. The residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane) to give the desired product. LCMS calculated for C15H17N4O2S (M+H)+: m/z=317.1. Found: 317.0.

1. washthe resulting mixture was washed with sat. NaHCO3 solution, water and brine
2. concentrationconcentrated
3. customThe residue was purified on silica gel (eluting with 0 to 5% MeOH in dichloromethane)