HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 711989Generated: October 30, 2026
Diisopropylethylamine → HCID 86717452, compound
https://huagongshe.com/reaction/711989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | 7-Chloro-6-nitrothieno[3,2-b]pyridine | HCID 14207950 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86717452 | HCID 86717452 | 83% |
Reaction Steps
A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.48 g, 2.2 mmol) (Example 1, Step 2), tert-butyl 4-aminopiperidine-1-carboxylate (from Aldrich, 0.67 g, 3.4 mmol) and N,N-diisopropylethylamine (1.2 mL, 6.7 mmol) in isopropyl alcohol (7.6 mL) was heated at 90° C. for 2 h. The precipitate was washed with isopropyl alcohol to give the desired product (0.70 83%). LCMS calculated for C17H23N4O4S (M+H)+: m/z=379.1. Found: 379.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181271B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-65ae4f83a0f84c0aac37e1b5c6f4f4f7 |
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| Source note | uspto-grants-2015_11 |
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