Hydrochloric Acid → HCID 86717462, compound

HRID 712002Notes

Reaction equation

HRID 712002 reaction equation
[C:1]([O:4][CH2:5][CH:6]1[CH:11]=[CH:10][C@H:9]([NH:12]C(OC(C)(C)C)=O)[CH2:8][O:7]1)(=[O:3])[CH3:2].Cl.O1CCOCC1>C(Cl)Cl>[C:1]([O:4][CH2:5][CH:6]1[CH:11]=[CH:10][C@H:9]([NH2:12])[CH2:8][O:7]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86717461HCID 86717461, compound

Product 1

HCID 86717462HCID 86717462, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of {(5S)-5-[(tert-butoxycarbonyl)amino]-5,6-dihydro-2H-pyran-2-yl}methyl acetate (205 mg, 0.756 mmol) in methylene chloride (5.2 mL) was added 4.0 M hydrogen chloride in dioxane (1.5 mL, 6.0 mmol). The reaction solution was stirred at room temperature for 6 h. The solvent was removed under reduced pressure to give the desired product as white solid. LCMS calculated for C8H14NO3 (M+H)+: m/z=172.1. Found: 172.1.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-f05d063b20a54e798ebc60fb57711320
Source dataset
uspto-grants-2015_11
Patent number
US09181271B2

Reaction notes

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