HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712008Generated: October 29, 2026
Triethylamine → N-[(2S)-Bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine
https://huagongshe.com/reaction/712008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Exo-2-bornanamine | HCID 98480 | — |
| Reactant | 7-Chloro-6-nitrothieno[3,2-b]pyridine | HCID 14207950 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-[(2S)-Bicyclo[2.2.1]hept-2-yl]-6-nitrothieno[3,2-b]pyridin-7-amine | HCID 86717467 | — |
Reaction Steps
A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (0.064 g, 0.30 mmol) (Example 1, Step 2), bicyclo[2.2.1]heptan-2-amine (from Aldrich, 0.050 g, 0.45 mmol) and triethylamine (0.083 mL, 0.60 mmol) in isopropyl alcohol (1.4 mL) was heated at 90° C. for 2 h. The mixture was concentrated to give the desired product, which was used in the next step without further purification. LCMS calculated for C14H16N3O2S (M+H)+: m/z=290.1. Found: 290.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181271B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-54ef6981dadd4cf3a965b36f16d96355 |
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| Source note | uspto-grants-2015_11 |
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