1,4-Dioxane hydrochloride → HCID 66977253, compound

HRID 712228Notes

Reaction equation

HRID 712228 reaction equation
[CH3:1][S:2][C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:21].O1CCOCC1>O1CCOCC1>[ClH:21].[CH3:1][S:2][C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66977220HCID 66977220, compound

Product 1

HCID 66977253HCID 66977253, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice-cold solution of O1-tert-butyl O4-ethyl 4-methylsulfanylpiperidine-1,4-dicarboxylate (0.23 g, 7.75 mmol) in 1,4-dioxane (20 mL) was added HCl-dioxane (4 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (by TLC), the solvent was evaporated to obtain a brownish solid material (0.17 g) that was carried forward to the next step without further purification. MS: 204.10 [M+H]+.

Workup

  1. customAfter completion of reaction (by TLC)
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-c1060ffd751c425ca533159ecbd33a12
Source dataset
uspto-grants-2015_11
Patent number
US09181234B2

Reaction notes

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