1,4-Dioxane hydrochloride → HCID 66977111, compound

HRID 712237Notes

Reaction equation

HRID 712237 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[F:22][C:2]([F:1])([F:21])[C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21054722HCID 21054722, compound

Product 1

HCID 66977111HCID 66977111, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-(trifluoromethyl)piperidine-1,4-dicarboxylate (0.15 g, 0.19 mmol) in 1,4-dioxane (10 mL) was added HCl-1,4-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (by TLC), solvent was evaporated to obtain brownish solid material (0.12 g) that was carried forward to the next step (i.e. synthesis of Compound 142) without purification. MS: 226.12 [M+H]+.

Workup

  1. customAfter completion of reaction (by TLC), solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-d4c1feb5f2e641fdadf3258ed01feeab
Source dataset
uspto-grants-2015_11
Patent number
US09181234B2

Reaction notes

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