1,4-Dioxane hydrochloride → HCID 66977111, compound

Participants

Reaction Steps

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-(trifluoromethyl)piperidine-1,4-dicarboxylate (0.15 g, 0.19 mmol) in 1,4-dioxane (10 mL) was added HCl-1,4-dioxane (4.0 M, 15 mL) solution and the mixture stirred at rt for 30 min. After completion of reaction (by TLC), solvent was evaporated to obtain brownish solid material (0.12 g) that was carried forward to the next step (i.e. synthesis of Compound 142) without purification. MS: 226.12 [M+H]+.

Provenance & Evidence