HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712373Generated: October 30, 2026
L-Methionine → 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
https://huagongshe.com/reaction/712373
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Methionine | HCID 6137 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6,7-Dimethoxy-3H-quinazolin-4-one | HCID 135495016 | — |
| Solvent | Methanesulfonic Acid | HCID 6395 | — |
| Product | 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one | HCID 135446413 | 123.3% |
Reaction Steps
A suspension of 6,7-dimethoxyquinazolin-4(3H)-one (6.18 g), methionine (4.70 g) and methanesulfonic acid (40 mL) was stirred at 130° C. for 3 h, then poured into ice-water. The reaction mixture was adjusted to pH 7 with 40% sodium hydroxide. The mixture was filtered to give the title compound (7.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181277B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-f6335b648f77422289b54b80798859a6 |
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| Source note | uspto-grants-2015_11 |
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