反应详情

温度

130 °C

A suspension of 6,7-dimethoxyquinazolin-4(3H)-one (6.18 g), methionine (4.70 g) and methanesulfonic acid (40 mL) was stirred at 130° C. for 3 h, then poured into ice-water. The reaction mixture was adjusted to pH 7 with 40% sodium hydroxide. The mixture was filtered to give the title compound (7.10 g).

1. filtrationThe mixture was filtered