反应详情

温度

83 °C

A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (4.31 g), 3-ethynylaniline (3.00 g) and isopropanol (65 mL) was stirred at 83° C. overnight. The reaction mixture was cooled to room temperature and filtered, the residue was washed with 100 mL of isopropanol and dried to afford the desired compound as a solid (4.89 g, 85.90%)

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationfiltered
3. washthe residue was washed with 100 mL of isopropanol
4. customdried