HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712412Generated: October 30, 2026
4-Bromo-2-fluoroaniline → 4-((4-Bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
https://huagongshe.com/reaction/712412
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| Reactant | 4-Chloro-7-methoxyquinazolin-6-yl acetate | HCID 22022160 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-((4-Bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate | HCID 21098397 | 84.5% |
Reaction Steps
A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (2.05 g), 4-bromo-2-fluoroaniline (2.11 g, 1.30 eq) and isopropanol (40 mL) was stirred at 83° C. overnight. The reaction mixture was cooled to room temperature and filtered, the residue was washed with 100 mL of isopropanol and dried to afford the desired compound as a solid (2.78 g, 84.50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181277B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-e5a21b178450487a9a45dc92ca415f40 |
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| Source note | uspto-grants-2015_11 |
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