反应详情

温度

83 °C

A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (2.05 g), 4-bromo-2-fluoroaniline (2.11 g, 1.30 eq) and isopropanol (40 mL) was stirred at 83° C. overnight. The reaction mixture was cooled to room temperature and filtered, the residue was washed with 100 mL of isopropanol and dried to afford the desired compound as a solid (2.78 g, 84.50%).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationfiltered
3. washthe residue was washed with 100 mL of isopropanol
4. customdried