3,4-Dihydro-2H-pyrano[3,2-b]pyridine → HCID 68842904, compound
Reaction equation
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>COCCO.[Pd]>[O:1]1[CH:10]2[CH:5]([NH:6][CH2:7][CH2:8][CH2:9]2)[CH2:4][CH2:3][CH2:2]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 70 °C
Procedure
To a solution of 3,4-dihydro-2H-pyrano[3,2-b]pyridine (0.60 g) in glycol monomethyl ether was added a catalytic amount of 10% Pd/C. The reaction mixture was stirred at 70° C. for 3 hours under H2 (2 MPa) and filtered. The filtrate was concentrated in vacuo to give the title compound as colorless oil (0.56 g, 90.00%), which was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 142.2 (M+1).
Workup
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
Sources & evidence
- ORD record
- ord-e0f1bc4483db4428b9c6b93ce7361e3c
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181277B2
Reaction notes
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