反应详情

To a solution of ethyl 4-(1-phenylcyclohexyl)butanoate (0.211 g, 0.77 mmol) in MeOH (5 mL) was added 1M sodium hydroxide (1.155 mL, 1.155 mmol) and the mixture was stirred at room temp for 5 hrs. Then additional 0.39 ml of 1M NaOH was added and stirring was continued for 3 hrs. To the mixture was added 2 ml of 1N HCl and extracted with EtOAc (2×). The combined extracts were washed with brine, dried over Na2SO4 and evaporated to give an oily residue, which became white solid upon storing at room temp.

1. stirringstirring
2. waitwas continued for 3 hrs
3. extractionextracted with EtOAc (2×)
4. washThe combined extracts were washed with brine
5. dry with materialdried over Na2SO4
6. customevaporated
7. customto give an oily residue, which
8. customupon storing at room temp.