Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712696Generated: October 29, 2026

Urea → 6-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

https://huagongshe.com/reaction/712696

Reaction equation

Participants

RoleNameHCIDCharge
ReactantUreaHCID 1176—
Reactant1-[3-Chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanolHCID 117667165—
Product6-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amideHCID 86305369—

Reaction Steps

6-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide is synthesized according to the procedure of Urea Formation Method II using 1-[3-chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181272B2
Source datasetuspto-grants-2015_11
ORD IDord-c23e8e8bb50e441ab8871c84487ae5e1
Source noteuspto-grants-2015_11