Urea → 6-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

HRID 712696Notes

Reaction equation

HRID 712696 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[Cl:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:15]2[CH:16]=[N:17][C:18]3N[CH2:20][CH2:21][CH2:22][C:23]=3[CH:24]=2)[C:11]=1[CH:12]([OH:14])[CH3:13]>>[Cl:5][C:6]1[C:11]([CH:12]([OH:14])[CH3:13])=[C:10]([C:15]2[CH:24]=[C:23]3[C:18](=[N:17][CH:16]=2)[N:1]([C:2]([NH2:4])=[O:3])[CH2:20][CH2:21][CH2:22]3)[CH:9]=[N:8][CH:7]=1

Participants

3

Reactant 2

HCID 1176UreaHCID 1176671651-[3-Chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol

Product 1

HCID 863053696-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

Procedure

6-[5-Chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide is synthesized according to the procedure of Urea Formation Method II using 1-[3-chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol.

Sources & evidence

ORD record
ord-c23e8e8bb50e441ab8871c84487ae5e1
Source dataset
uspto-grants-2015_11
Patent number
US09181272B2

Reaction notes

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