Urea → 6-[4-(1-Hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide
Reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[N:5]1[C:14]2N[CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[C:7]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][C:20]=2[CH:21]([OH:23])[CH3:22])[CH:6]=1>>[OH:23][CH:21]([C:20]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:7]1[CH:8]=[C:9]2[C:14](=[N:5][CH:6]=1)[N:1]([C:2]([NH2:4])=[O:3])[CH2:12][CH2:11][CH2:10]2)[CH3:22]Participants
3
Procedure
The titled product is synthesized according to the procedure of Urea Formation Method II using 1-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol.
Sources & evidence
- ORD record
- ord-c9c4b1dd999741dabe1377ac002ad467
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181272B2
Reaction notes
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