反应详情

温度

150 °C

To a solution of 4-(1-benzyloxy-ethyl)-3,5-dibromo-pyridine (400 mg, 1.1 mmol) in DMF (5 mL) is added copper cyanide (116 mg, 1.3 mmol). The mixture is heated and stirred at 150° C. for 3 h, then stirred at room temperature for 16 h. H2O is added and the mixture is extracted with EtOAc. The organic layers are combined and concentrated to give the crude product. Purification by flash column chromatography provides 225 mg of 4-(1-benzyloxy-ethyl)-5-bromo-nicotinonitrile.

1. temperatureThe mixture is heated
2. stirringstirred at room temperature for 16 h
3. extractionthe mixture is extracted with EtOAc
4. concentrationconcentrated
5. customto give the crude product
6. customPurification by flash column chromatography