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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712709Generated: October 29, 2026

Urea → 6-[4-(1-Benzyloxy-ethyl)-5-cyano-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

https://huagongshe.com/reaction/712709

Reaction equation

Participants

RoleNameHCIDCharge
ReactantUreaHCID 1176—
Reactant4-(1-Benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrileHCID 117667455—
Product6-[4-(1-Benzyloxy-ethyl)-5-cyano-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amideHCID 117667795—

Reaction Steps

The titled product is synthesized according to the procedure of Urea Formation Method II using 4-(1-benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181272B2
Source datasetuspto-grants-2015_11
ORD IDord-f853f1c4abfa45908d454a64106f4af7
Source noteuspto-grants-2015_11