Urea → 6-[4-(1-Benzyloxy-ethyl)-5-cyano-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

HRID 712709Notes

Reaction equation

HRID 712709 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[CH2:5]([O:12][CH:13]([C:15]1[C:20]([C:21]#[N:22])=[CH:19][N:18]=[CH:17][C:16]=1[C:23]1[CH:24]=[N:25][C:26]2N[CH2:28][CH2:29][CH2:30][C:31]=2[CH:32]=1)[CH3:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[CH2:5]([O:12][CH:13]([C:15]1[C:20]([C:21]#[N:22])=[CH:19][N:18]=[CH:17][C:16]=1[C:23]1[CH:32]=[C:31]2[C:26](=[N:25][CH:24]=1)[N:1]([C:2]([NH2:4])=[O:3])[CH2:28][CH2:29][CH2:30]2)[CH3:14])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 1176UreaHCID 1176674554-(1-Benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile

Product 1

HCID 1176677956-[4-(1-Benzyloxy-ethyl)-5-cyano-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

Procedure

The titled product is synthesized according to the procedure of Urea Formation Method II using 4-(1-benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile.

Sources & evidence

ORD record
ord-f853f1c4abfa45908d454a64106f4af7
Source dataset
uspto-grants-2015_11
Patent number
US09181272B2

Reaction notes

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