Urea → HCID 117667090, compound

HRID 712711Notes

Reaction equation

HRID 712711 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[CH2:5]([O:12][C:13](=[O:31])[CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[CH:22]=[N:23][C:24]3N[CH2:26][CH2:27][CH2:28][C:29]=3[CH:30]=2)[CH:20]=1)[C:6]1C=CC=CC=1>>[CH2:5]([O:12][C:13](=[O:31])[CH2:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([C:21]2[CH:22]=[N:23][C:24]3[N:1]([C:2](=[O:3])[NH2:4])[CH2:26][CH2:27][CH2:28][C:29]=3[CH:30]=2)[CH:20]=1)[CH3:6]

Participants

3

Reactant 2

HCID 1176UreaHCID 117667595HCID 117667595, compound

Product 1

HCID 117667090HCID 117667090, compound

Procedure

[5-(8-Carbamoyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-acetic acid ethyl ester is synthesized according to the procedure of Urea Formation Method I using [5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-acetic acid benzyl ester.

Sources & evidence

ORD record
ord-4289eeacb9924363ae41164c0786d8fd
Source dataset
uspto-grants-2015_11
Patent number
US09181272B2

Reaction notes

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