HRID712715

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID117667681

未命名化合物

结构：CC(C)(C)OC(=O)N1CCCc2cc(B3OC(C)(C)C(C)(C)O3)cnc21

HCID123216343

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCCc2cc(-c3cncc(C(C)(C)C(=O)OCc4ccccc4)c3)cnc21

HCID117667357

未命名化合物

PROCEDURE

实验过程

6-[5-(1-Benzyloxycarbonyl-1-methyl-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester is synthesized according to the procedure of Suzuki Coupling Method VI using 2-(5-bromo-pyridin-3-yl)-2-methyl-propionic acid benzyl ester and crude 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (Intermediate G).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0e9a216bdf2249be8a68e5b06db44190
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09181272B2
来源说明: uspto-grants-2015_11

反应 SMILES

[CH2:1]([O:8][C:9](=[O:20])[C:10]([C:13]1[CH:14]=[N:15][CH:16]=[C:17](Br)[CH:18]=1)([CH3:12])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O:25][C:26]([N:28]1[C:37]2[C:32](=[CH:33][C:34](B3OC(C)(C)C(C)(C)O3)=[CH:35][N:36]=2)[CH2:31][CH2:30][CH2:29]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26]([N:28]1[C:37]2[C:32](=[CH:33][C:34]([C:17]3[CH:16]=[N:15][CH:14]=[C:13]([C:10]([C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[O:20])([CH3:12])[CH3:11])[CH:18]=3)=[CH:35][N:36]=2)[CH2:31][CH2:30][CH2:29]1)=[O:27])([CH3:24])([CH3:22])[CH3:23]