HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Bromo-pyridin-3-yl)-2-methyl-propionic acid benzyl ester → 6-[5-(1-Benzyloxycarbonyl-1-methyl-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Bromo-pyridin-3-yl)-2-methyl-propionic acid benzyl ester | HCID 117667681 | — |
| Reactant | 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester | HCID 123216343 | — |
| Product | 6-[5-(1-Benzyloxycarbonyl-1-methyl-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester | HCID 117667357 | — |
Reaction Steps
6-[5-(1-Benzyloxycarbonyl-1-methyl-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester is synthesized according to the procedure of Suzuki Coupling Method VI using 2-(5-bromo-pyridin-3-yl)-2-methyl-propionic acid benzyl ester and crude 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (Intermediate G).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-0e9a216bdf2249be8a68e5b06db44190 |
| Source note | uspto-grants-2015_11 |