Urea → 6-[5-(1,1-Dimethyl-2-morpholin-4-yl-2-oxo-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

HRID 712718Notes

Reaction equation

HRID 712718 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[CH3:5][C:6]([C:16]1[CH:17]=[N:18][CH:19]=[C:20]([C:22]2[CH:23]=[N:24][C:25]3N[CH2:27][CH2:28][CH2:29][C:30]=3[CH:31]=2)[CH:21]=1)([CH3:15])[C:7]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[O:8]>>[CH3:5][C:6]([C:16]1[CH:21]=[C:20]([C:22]2[CH:31]=[C:30]3[C:25](=[N:24][CH:23]=2)[N:1]([C:2]([NH2:4])=[O:3])[CH2:27][CH2:28][CH2:29]3)[CH:19]=[N:18][CH:17]=1)([CH3:15])[C:7]([N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)=[O:8]

Participants

3

Reactant 2

HCID 1176UreaHCID 1176676792-Methyl-1-morpholin-4-yl-2-[5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-propan-1-one

Product 1

HCID 1176678086-[5-(1,1-Dimethyl-2-morpholin-4-yl-2-oxo-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

Procedure

The titled product is synthesized according to the procedure of Urea Formation Method II using 2-methyl-1-morpholin-4-yl-2-[5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-propan-1-one.

Sources & evidence

ORD record
ord-2aad5a15bafb4baf89d057cccdaca9d2
Source dataset
uspto-grants-2015_11
Patent number
US09181272B2

Reaction notes

Loading…