HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → HCID 117667419, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-(5-Bromopyridin-3-yl)cyclopropane-1-carbonitrile | HCID 67056000 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 117667419 | HCID 117667419 | — |
Reaction Steps
1-(5-Bromo-pyridin-3-yl)-cyclopropanecarbonitrile (150 mg, 0.672 mmol) is dissolved in THF (1.5 mL) in a reaction vial. Ammonium hydroxide (1 mL) is then added. Hydrogen peroxide (30% aq solution, 0.5 mL) is added slowly. The mixture is stirred at room temperature for 4 h. The volatiles is evaporated to afford 1-(5-bromo-pyridin-3-yl)-cyclopropanecarboxylic acid amide (157.5 mg, 97% crude yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-147bca29d8a04160a7703d83bb7e661a |
| Source note | uspto-grants-2015_11 |