Hydrogen Peroxide → HCID 117667419, compound

HRID 712759Notes

Reaction equation

HRID 712759 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[OH-:13].[NH4+].OO>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:11]([NH2:12])=[O:13])[CH2:9][CH2:10]2)[CH:5]=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14923Ammonium HydroxideHCID 670560001-(5-Bromopyridin-3-yl)cyclopropane-1-carbonitrile

Product 1

HCID 117667419HCID 117667419, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(5-Bromo-pyridin-3-yl)-cyclopropanecarbonitrile (150 mg, 0.672 mmol) is dissolved in THF (1.5 mL) in a reaction vial. Ammonium hydroxide (1 mL) is then added. Hydrogen peroxide (30% aq solution, 0.5 mL) is added slowly. The mixture is stirred at room temperature for 4 h. The volatiles is evaporated to afford 1-(5-bromo-pyridin-3-yl)-cyclopropanecarboxylic acid amide (157.5 mg, 97% crude yield).

Workup

  1. customThe volatiles is evaporated

Sources & evidence

ORD record
ord-147bca29d8a04160a7703d83bb7e661a
Source dataset
uspto-grants-2015_11
Patent number
US09181272B2

Reaction notes

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