HCID 86731612, compound → 2-Methyl-D-proline methyl ester hydrochloride

HRID 712818Notes

Reaction equation

HRID 712818 reaction equation
[CH3:1][C@:2]12[CH2:14][CH2:13][CH2:12][N:3]1[CH:4](C(Cl)(Cl)[Cl:9])[O:5][C:6]2=[O:7]>CO.Cl>[ClH:9].[CH3:1][C@:2]1([C:6]([O:5][CH3:4])=[O:7])[CH2:14][CH2:13][CH2:12][NH:3]1

Participants

4

Reactant 1

HCID 86731612HCID 86731612, compound

Product 1

HCID 713062052-Methyl-D-proline methyl ester hydrochlorideYield 0.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent2×

Procedure

To a solution of (7aR)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (D49) (0.11 g, 0.42 mol) in dry MeOH (2 ml), HCl 1M sol in MeOH (0.3 ml, 0.85 mol) was added and the mixture refluxed under a constant current of nitrogen for 1 h. Solvent was evaporated to afford the title compound (D50) 60 mg.

Workup

  1. additionwas added
  2. temperaturethe mixture refluxed under a constant current of nitrogen for 1 h
  3. customSolvent was evaporated

Sources & evidence

ORD record
ord-a7b894edf32d419aacb20902bf761334
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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