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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712819Generated: October 30, 2026

(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acid → (R)-tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

https://huagongshe.com/reaction/712819

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acidHCID 688618—
ReactantMethyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
Product(R)-tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylateHCID 8673161978.2%

Reaction Steps

The title compound (D53) (650 mg) was prepared according to the general procedure for amides preparation (Method A) starting from (R)-1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid (500 mg, available from Sigma Aldrich #516341), and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (470 mg). Reaction time: 18 hrs.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-62db683583f4490f84ad60d8479d251c
Source noteuspto-grants-2015_11