(2R)-1-Boc-4-oxopipecolic acid → HCID 117966684, compound

HRID 712823Notes

Reaction equation

HRID 712823 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][C@@H:9]1[C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:19][C@H:20]([C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][CH:23]=1)[CH3:21]>>[CH3:29][O:28][C:26]([C:25]1[CH:30]=[CH:31][C:22]([C@@H:20]([NH:19][C:15]([C@H:9]2[CH2:10][C:11](=[O:14])[CH2:12][CH2:13][N:8]2[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[O:17])[CH3:21])=[CH:23][CH:24]=1)=[O:27]

Participants

3

Reactant 2

HCID 44119498(2R)-1-Boc-4-oxopipecolic acidHCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride

Product 1

HCID 117966684HCID 117966684, compound

Procedure

The title compound (D60) (300 mg) was prepared according to the general procedure for amides preparation (Method C) starting from (R)-1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid (200 mg; available from Aldrich#701130) and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (195 mg). Reaction time: 1 h

Workup

  1. customReaction time
  2. custom1 h

Sources & evidence

ORD record
ord-94da9934035348c2bb8657dec5d572d7
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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