1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acid → Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	1-((Tert-butoxy)carbonyl)-4,4-difluoropiperidine-2-carboxylic acid	HCID 10106900	—
Reactant	Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride	HCID 66824369	—
Product	Tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate	HCID 117966874	69.4%

Reaction Steps

The title compound (D68) (688 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid (600 mg; described in WO2010148197) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (566.5 mg). Reaction time: 5 hrs

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181279B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-f42d9d81c8d142c3b6715110002965ae
Source note	uspto-grants-2015_11