1-benzylazetidine-2-carboxylic acid → HCID 71186307, compound

HRID 712832Notes

Reaction equation

HRID 712832 reaction equation
[CH2:1]([N:8]1[CH2:11][CH2:10][CH:9]1[C:12]([OH:14])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:16][C@H:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][CH:20]=1)[CH3:18]>>[CH2:1]([N:8]1[CH2:11][CH2:10][CH:9]1[C:12]([NH:16][C@H:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][CH:20]=1)[CH3:18])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2889361-benzylazetidine-2-carboxylic acidHCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride

Product 1

HCID 71186307HCID 71186307, compoundYield 53.2%

Procedure

The title compound (D76) (98 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-benzylazetidine-2-carboxylic acid (100 mg, available from Apollo#OR7040) and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (113 mg). Reaction time: 1 h

Workup

  1. customReaction time
  2. custom1 h

Sources & evidence

ORD record
ord-83f076cccdb742349530cc10143933be
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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