Sodium Carbonate → HCID 89350949, compound

HRID 712833Notes

Reaction equation

HRID 712833 reaction equation
[CH3:1][C@:2]1([C:8]([OH:10])=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][NH:3]1.[F:11][C:12]([F:22])([F:21])[C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:1][C@:2]1([C:8]([O:10][CH2:17][C:16]2[CH:15]=[CH:14][C:13]([C:12]([F:11])([F:21])[F:22])=[CH:20][CH:19]=2)=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:17][C:16]1[CH:19]=[CH:20][C:13]([C:12]([F:22])([F:21])[F:11])=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 132055972-Methylpiperidine-2-carboxylic acid

Product 1

HCID 89350949HCID 89350949, compound

Procedure

The title compound (D79) (70 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-2-methylpiperidine-2-carboxylic acid (D47) (60 mg) and 4-(Trifluoromethyl)benzyl bromide (0.126 ml). (Na2CO3: 8 eq; reaction time 48 hrs; 68° C.)

Sources & evidence

ORD record
ord-08f8e865b3d74e9ebb9b3eea3275ab08
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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