Sodium Carbonate → HCID 71204723, compound

HRID 712834Notes

Reaction equation

HRID 712834 reaction equation
Cl.[CH3:2][C@:3]1([C:8]([O:10][CH3:11])=[O:9])[CH2:7][CH2:6][CH2:5][NH:4]1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:2][C@:3]1([C:8]([O:10][CH3:11])=[O:9])[CH2:7][CH2:6][CH2:5][N:4]1[CH2:18][C:17]1[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:22])[F:23])=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 713062052-Methyl-D-proline methyl ester hydrochloride

Product 1

HCID 71204723HCID 71204723, compound

Procedure

The title compound (D80) (50 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from (R)-methyl 2-methylpyrrolidine-2-carboxylate hydrochloride (D50) (60 mg) and 4-(Trifluoromethyl)benzyl bromide (0.126 ml). (Na2CO3: 4 eq; reaction time 18 hrs; 68° C.)

Sources & evidence

ORD record
ord-4715911ba7804d8f9354213686d420ca
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

Loading…