HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 71186605, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 117966881 | HCID 117966881 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 71186605 | HCID 71186605 | — |
Reaction Steps
tert-butyl 5-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate (D55) (19.7 g) was dissolved in DCM (220 ml) before adding TFA (35 ml). The reaction was stirred at RT for 18 hrs. After solvent evaporation the title compound (D89) (27 g) was isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-30f02e0ad9c546d58c578a0d69dc450a |
| Source note | uspto-grants-2015_11 |