Trifluoroacetic acid → HCID 71186605, compound

HRID 712839Notes

Reaction equation

HRID 712839 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2([NH:14][C:15]([CH:17]3[N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22][C:19]4([CH2:21][CH2:20]4)[CH2:18]3)=[O:16])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)=[O:4].[C:32]([OH:38])([C:34]([F:37])([F:36])[F:35])=[O:33]>C(Cl)Cl>[F:35][C:34]([F:37])([F:36])[C:32]([OH:38])=[O:33].[CH2:20]1[C:19]2([CH2:22][CH2:23][NH:24][CH:17]([C:15]([NH:14][C:11]3([C:8]4[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=4)[CH2:12][CH2:13]3)=[O:16])[CH2:18]2)[CH2:21]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117966881HCID 117966881, compound

Product 1

HCID 71186605HCID 71186605, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 5-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate (D55) (19.7 g) was dissolved in DCM (220 ml) before adding TFA (35 ml). The reaction was stirred at RT for 18 hrs. After solvent evaporation the title compound (D89) (27 g) was isolated.

Workup

  1. customAfter solvent evaporation the title compound (D89) (27 g)
  2. customwas isolated

Sources & evidence

ORD record
ord-30f02e0ad9c546d58c578a0d69dc450a
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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